Basic Info

Serotype prediction based on their surface antigens, such as O, H, and K antigens.

More Details

The serotype represents the genetic markers displayed by proteins in blood plasma. Due to the genetic polymorphism of some serum proteins, phenotypic differences arise among individuals. Therefore, serotyping has become an important classification method, especially for many foodborne microorganisms such as Salmonella and Listeria monocytogenes. This method is also widely used in epidemiological investigations. By determining the serotype of bacteria, we can provide a solid basis for antimicrobial therapy. Specifically, through in-depth analysis of the characteristics of bacterial somatic cells, such as the O antigen, cell surface proteins, H antigen, and K antigen, we can accurately classify bacteria based on their serotypes.

What's New

The Group B Streptococcus (GBS) is encapsulated by a layer of capsular polysaccharide (CP), and the serotypes determined by CP are referred to as CPS. Based on the immunoreactivity of the CP in GBS, ten serotypes (Ia, Ib, II, III, IV, V, VI, VII, VIII, IX) and nontypeable (NT) strains have been identified. CPS can be detected and identified through molecular biological methods such as latex agglutination and multiplex PCR. The most common CPS serotypes of GBS include Ia, Ib, II, III, and V.

Additional Information

NA

Literature

Russell NJ, Seale AC, O'Driscoll M, et al. Maternal Colonization With Group B Streptococcus and Serotype Distribution Worldwide: Systematic Review and Meta-analyses. Clin Infect Dis. 2017;65(suppl_2):S100-S111. doi:10.1093/cid/cix658.

Kong F, Gowan S, Martin D, James G, Gilbert GL. Serotype identification of group B streptococci by PCR and sequencing. J Clin Microbiol. 2002;40(1):216-226. doi:10.1128/JCM.40.1.216-226.2002.

Wen L, Wang Q, Li Y, et al. Use of a serotype-specific DNA microarray for identification of group B Streptococcus (Streptococcus agalactiae). J Clin Microbiol. 2006;44(4):1447-1452. doi:10.1128/JCM.44.4.1447-1452.2006