Application Information
Basic Info
Serotype prediction based on their surface antigens, such as O, H, and K antigens.
More Details

The serotype represents the genetic markers displayed by proteins in blood plasma. Due to the genetic polymorphism of some serum proteins, phenotypic differences arise among individuals. Therefore, serotyping has become an important classification method, especially for many foodborne microorganisms such as Salmonella and Listeria monocytogenes. This method is also widely used in epidemiological investigations. By determining the serotype of bacteria, we can provide a solid basis for antimicrobial therapy. Specifically, through in-depth analysis of the characteristics of bacterial somatic cells, such as the O antigen, cell surface proteins, H antigen, and K antigen, we can accurately classify bacteria based on their serotypes.

What's New
Capsular polysaccharide (CPS) is a clinically significant virulence factor in Campylobacter jejuni. The structural diversity of CPS primarily manifests in variations of glycosyl composition and linkage patterns, particularly those involving heptose with unique configurations and O-methyl phosphoramidate linkages. The high variability of CPS structure aligns with the major serodeterminants of the Penner serotyping scheme, which serves as the gold standard for C. jejuni classification, categorizing strains into 47 serotypes. The Penner serotyping scheme, a passive slide hemagglutination assay primarily based on CPS, initially described 23 serotypes in its seminal publication and was subsequently expanded to 47 serotypes, despite the existence of cross-reactive complexes among many serotypes. 
The serotypes HS4, HS2, and HS1 are globally predominant. Among these, the HS4 complex is the most prevalent, accounting for 13.2% of cases, followed by HS2 (7.96%) and the HS1 complex (6.81%). Penner serotypes HS3, HS5, and HS8 also demonstrate global prevalence, while other serotypes tend to exhibit geographic and population-specific variations.
Additional Information

NA

Literature

Penner JL, Hennessy JN. Passive hemagglutination technique for serotyping Campylobacter fetus subsp. jejuni on the basis of soluble heat-stable antigens. J Clin Microbiol. 1980;12(6):732-737. doi:10.1128/jcm.12.6.732-737.1980

Guerry P, Poly F, Riddle M, Maue AC, Chen YH, Monteiro MA. Campylobacter polysaccharide capsules: virulence and vaccines. Front Cell Infect Microbiol. 2012;2:7. doi:10.3389/fcimb.2012.00007

Zang XQ.Genetic evolution, host adaptation and pathogenicity of Campylobacter jejuni isolates from different sources. Yangzhou University. 2024.DOI:10.27441/d.cnki.gyzdu.2024.000118.

About
  • APPID: 4ddf4
  • Compute cost: Free
  • Running time: < 5min
  • Current version: 1.0.0
  • Last update: 2025-07-10