Basic Info

Using Tuberculosis Lineage Genotyping (TbLG) technology, we can rapidly and accurately classify the lineages of Mycobacterium tuberculosis Complex (MTBC) isolates

More Details

MTBC can currently be categorized into 169 lineages and sublineages of M. tuberculosis/M. africanum, along with nine animal-adapted species, based on SNP-based genotyping. The phylogenetic analysis of animal-adapted species were classified into four distinct clades, namely A1 through A4. The classification system employs a hierarchical approach, with five levels of detail. The first level represents the main phylogenetic lineage or species, while the final level represents the most refined phylogroup.

 

What's New

TbLG is a Python-based command-line tool that facilitates the classification of MTBC lineages from a VCF file. It employs a curated panel of reference barcoding SNPs, to ensure precise lineage classification.

Additional Information

Related links:

https://github.com/dbespiatykh/tblg

Literature

Shitikov E, Bespiatykh D. A revised SNP-based barcoding scheme for typing Mycobacterium tuberculosis complex isolates. mSphere. 2023;8(4):e0016923. doi:10.1128/msphere.00169-23